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Verified Claims: 42
Scientific Sources: 17
Phthalates are a group of chemicals, mainly used as plasticizers, to increase the flexibility, transparency, durability, and longevity of plastics, especially polyvinyl chloride (PVC) [29], [5]. They are also used as color and scent stabilizers in personal care products [13].
Di(2-ethylhexyl) phthalate (DEHP) was developed and quickly adopted for commercial use in polyvinyl chloride (PVC) production [6].
Global phthalate production more than doubled by 2006, increasing from 1.8 to 4.3 million tons [6].
EFSA performed risk assessments of DBP, BBP, DEHP, DINP, and DIDP [9].
Phthalates can act as endocrine disruptors, interfering with the body's hormones and potentially leading to reproductive toxicity, declines in fertility, reduced testis weight, and increased oxidative stress on reproductive organs [5], [6], [12], [20].
Exposure to phthalates has been associated with metabolic effects, including an increased risk of type II diabetes, neurodevelopment impairment, obesity, cancer, and cardiovascular mortality [6], [7], [8].
Prenatal phthalate exposure may affect newborn brain development by altering the metabolism of neurotransmitters and amino acids [23].
Phthalate exposure has been linked to premature birth, infertility, and ADHD [18], [20].
Phthalates and attributable mortality: a population-based longitudinal cohort study and cost analysis
Phthalate exposure is associated with increased mortality [11].
Toxic effects of phthalates on in vitro cellular models: A systematic review and meta-analysis (2014–2024)
Phthalates can act as endocrine disruptors and can affect multiple body systems, impacting erythrocytes and the reproductive system. They have also been associated with oxidative stress, leading to cell degeneration and affecting organs such as the liver, kidney, brain, lung, and reproductive system [5].
Phthalate exposure and metabolic effects: a systematic review of the human epidemiological evidence
Phthalate exposures are associated with some metabolic effects, with associations with diabetes risk being strongest for DEHP, DBP, and DIBP [7], [8].
Filling gaps in population estimates of phthalate exposure globally: A systematic review and meta-analysis of international biomonitoring data
Phthalates are identified as endocrine-disrupting chemicals (EDCs) and have been linked to reproductive toxicity with prolonged exposure, causing declines in fertility, reduced testis weight, and increased oxidative stress on reproductive organs [6].
Contradictory. Some phthalates are regulated as toxins and banned in consumer goods in many countries [29]. The FDA allows nine phthalates in food contact applications [15].
While some studies suggest harmful effects, the FDA states that phthalates in cosmetics and other consumer products do not pose serious safety risks [35]. However, the FDA is generally aware of updated toxicological and use information on phthalates that is publicly available, but stakeholders may have access to information that is not always made public [15].
Adipate-based plasticizers
Can be used as plasticizers instead of phthalates for low-temperature applications [34].
Aliphatic esters based on dicarboxylic acids (sebacates and maleates)
Can be used as plasticizers instead of phthalates [34].
Epoxidized vegetable oils
Natural plasticizers that can be used as alternatives to phthalates [34].
Glass and steel food storage containers
Avoid plastic food storage containers [37].