PFAS
Summary
What it is
Common uses
Public Perception
Anxiety level
Cultural claims
Source sentiment
History
Timeline
Origin
Science
Key findings
Studies
Safety status
Nuance
Alternatives
Swaps
Avoidance tips
References

Fact-checked by Lucent 3 months ago

PFAS

ingredientContaminants

Total Sources: 48

Verified Claims: 45

Scientific Sources: 16

Also known as: Per- and Polyfluoroalkyl Substances

Summary

Per- and polyfluoroalkyl substances (PFAS) are a group of thousands of synthetic chemicals used in various industries and consumer products for their water and oil-resistant properties [1], [11]. Known as "forever chemicals" due to their persistence in the environment and the human body, PFAS raise concerns about potential health risks [18], [27].

What it is

PFAS are a diverse group of synthetic organofluorine chemical compounds characterized by multiple fluorine atoms attached to an alkyl chain [1], [27]. This structure gives them unique properties, including thermal and chemical stability, as well as water and oil repellency [11], [28].

Common uses

  • Non-stick cookware [17], [21]

  • Waterproof and stain-resistant clothing and textiles [6], [21]

  • Food packaging (pizza boxes, takeout containers) [6], [21]

  • Firefighting foam [6], [11]

  • Cosmetics (waterproof mascara, shiny lip gloss) [17], [27]

Public Perception

Anxiety level

High. The term "forever chemicals" and reports of widespread contamination contribute to significant public anxiety [17], [18].

Cultural claims

  • PFAS are "forever chemicals" that accumulate in the environment and human bodies [11], [18].

  • Exposure to PFAS is ubiquitous, with nearly all Americans having detectable levels in their bodies [18], [25].

Source sentiment

News sources express concern over the widespread presence of PFAS and their potential health effects, emphasizing the need for action and regulation [17], [18].

History

Timeline

1938

Discovery of polytetrafluoroethylene (PTFE or Teflon) by DuPont [8], [26], [29].

1950

Widespread manufacturing and use of PFAS in consumer and industrial products begins [28].

1956

3M markets PFOS as Scotchgard [29].

1960

Revelation of human exposure to PFAS from manufacturing and application, marking the emergence of a global contamination crisis [11].

2000

PFAS widely documented in environmental samples [28].

2000

Safety concerns raised with certain PFAS substances [15].

2011

Grease-proofing agents containing long-chain PFAS compounds stopped being used for food contact use in the U.S. market between 2011 and 2016 [15].

2019

Many testify before Congress, urging lawmakers to take action on PFAS contamination [18].

2024

FDA announces PFAS used in grease-proofing agents for food packaging are no longer being sold in the U.S [15].

2025

FDA determines authorization for 35 Food Contact Notifications related to PFAS are no longer effective [16].

Origin

The first PFAS, polytetrafluoroethylene (PTFE or Teflon), was discovered accidentally by DuPont while researching new refrigerants [8], [26], [29].

First appeared: 1938

Science

Key findings

  • PFAS exposure is associated with increased risk of certain cancers, including kidney, liver, and testicular cancers [5], [11].

  • PFAS can disrupt the endocrine system, potentially leading to reproductive and developmental disorders [6], [11].

  • Exposure to PFAS may negatively impact the immune system [4], [10].

  • PFAS can cross the blood-brain barrier and accumulate in the brain, potentially leading to neurotoxicity [14].

Studies

Per- and Poly-fluoroalkyl Substances (PFAS) Exposure and Risk of Kidney, Liver, and Testicular Cancers: A Systematic Review and Meta-Analysis

An association was found between overall PFAS exposure and the risk of kidney cancers [5].

Association between exposure to per- and perfluoroalkyl substances (PFAS) and reproductive hormones in human: A systematic review and meta-analysis

PFAS exposure was significantly associated with reproductive hormone levels [6].

Risk to human health related to the presence of perfluoroalkyl substances in food

Parts of the European population exceed the tolerable weekly intake (TWI) of PFAS, which is of concern [10].

Neurotransmission Targets of Per- and Polyfluoroalkyl Substance Neurotoxicity: Mechanisms and Potential Implications for Adverse Neurological Outcomes

PFAS exposure causes neurotoxicity through the disruption of neurotransmission, particularly the dopamine and glutamate systems [14].

Safety status

Concerning. Exposure to certain PFAS has been linked to a range of adverse health effects [1], [11].

Nuance

The health effects of PFAS exposure can vary depending on the specific compound, exposure level, duration, and individual susceptibility [24].

Alternatives

Stainless steel or cast iron cookware

Avoids non-stick coatings containing PFAS [35], [36].

PFAS-free dental floss

Avoids PFAS used in some floss for easy sliding [37].

Where to find: Amazon, specialty stores [37]

Food containers made of glass or stainless steel

Reduces exposure from plastic containers that may contain PFAS [35], [38].

Avoidance tips

  • Check product labels for PFAS or related chemicals [38].

  • Choose restaurants and food packaging that have phased out PFAS [43].

  • Cook at home more often to reduce exposure from takeout containers [45].

  • Use a water filter certified to remove PFAS [20], [39].

References

1.

https://www.fda.gov/food/environmental-contaminants-food/and-polyfluoroalkyl-substances-pfas