Fact-checked by Lucent 3 months ago
Total Sources: 48
Verified Claims: 45
Scientific Sources: 16
Per- and polyfluoroalkyl substances (PFAS) are a group of thousands of synthetic chemicals used in various industries and consumer products for their water and oil-resistant properties [1], [11]. Known as "forever chemicals" due to their persistence in the environment and the human body, PFAS raise concerns about potential health risks [18], [27].
Widespread manufacturing and use of PFAS in consumer and industrial products begins [28].
3M markets PFOS as Scotchgard [29].
Revelation of human exposure to PFAS from manufacturing and application, marking the emergence of a global contamination crisis [11].
PFAS widely documented in environmental samples [28].
Safety concerns raised with certain PFAS substances [15].
Grease-proofing agents containing long-chain PFAS compounds stopped being used for food contact use in the U.S. market between 2011 and 2016 [15].
Many testify before Congress, urging lawmakers to take action on PFAS contamination [18].
FDA announces PFAS used in grease-proofing agents for food packaging are no longer being sold in the U.S [15].
FDA determines authorization for 35 Food Contact Notifications related to PFAS are no longer effective [16].
PFAS exposure is associated with increased risk of certain cancers, including kidney, liver, and testicular cancers [5], [11].
PFAS can disrupt the endocrine system, potentially leading to reproductive and developmental disorders [6], [11].
Exposure to PFAS may negatively impact the immune system [4], [10].
PFAS can cross the blood-brain barrier and accumulate in the brain, potentially leading to neurotoxicity [14].
Per- and Poly-fluoroalkyl Substances (PFAS) Exposure and Risk of Kidney, Liver, and Testicular Cancers: A Systematic Review and Meta-Analysis
An association was found between overall PFAS exposure and the risk of kidney cancers [5].
Association between exposure to per- and perfluoroalkyl substances (PFAS) and reproductive hormones in human: A systematic review and meta-analysis
PFAS exposure was significantly associated with reproductive hormone levels [6].
Risk to human health related to the presence of perfluoroalkyl substances in food
Parts of the European population exceed the tolerable weekly intake (TWI) of PFAS, which is of concern [10].
Neurotransmission Targets of Per- and Polyfluoroalkyl Substance Neurotoxicity: Mechanisms and Potential Implications for Adverse Neurological Outcomes
PFAS exposure causes neurotoxicity through the disruption of neurotransmission, particularly the dopamine and glutamate systems [14].
Concerning. Exposure to certain PFAS has been linked to a range of adverse health effects [1], [11].
The health effects of PFAS exposure can vary depending on the specific compound, exposure level, duration, and individual susceptibility [24].